Suprafer

Suprafer

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Suprafer

Dedicated name of the product

Suprafer

The general name of the product

Iron Bisglycinate, Folic Acid, Zinc sulphate monohydrate & Vitamins: B12, B9, B6, C

Indication & usage

Helps iron supplementation in:

  • Menstruating adult women & adolescent girls
  • Menorrhagia, pregnancy & lactation
  • Pernicious anemia
  • Helps in prevention of iron & folate deficiency anemia
  • Helps to maintain healthy energy & wellbeing

Composition

Each film coated tablet contains: Iron as iron bisglycinate (15%) 27 mg, Folic Acid 0.5 mg, Zinc sulphate monohydrate 11 mg, Vitamin B12 1000 mcg, Vitamin B6 1.3 mg, Vitamin C 90 mg.

Pharmacology and pharmacokinetics functions of the product

Iron is critical to a variety of physiologic processes, including respiration, energy production, and cell proliferation. About 65 to 80% of the body's iron is in the blood in the form of hemoglobin, a protein that transports oxygen to tissues in the body. In addition, iron is involved in reactions within the body that produce energy and any excess iron is stored in the body as a reserve.

Hemoglobin usually responds rapidly to effective oral iron therapy and increases of at least 2g/dL after three weeks of adequate therapy. However, repletion of iron stores and normalization of serum ferritin may require 4 to 6 months of treatment.

Folic Acid: The active forms of folic acid (dihydrofolate and tetrahydrofolate) are involved in a wide variety of biochemical reactions. A deficiency of folic acid impairs DNA synthesis and cell division; the common clinical manifestation of folic acid deficiency is megaloblastic anemia, which is hematologically similar to the anemia resulting from vitamin B12 deficiency.

Zinc: Zinc is critical to tissue growth, wound healing, immune system function, prostaglandin production, bone mineralization, proper thyroid function, blood clotting, cognitive functions, fetal growth and sperm production. Zinc may help in the treatment of pre-menstrual syndrome (PMS) by regulating the secretion of many hormones and natural pain management. In pregnant women, the lack of zinc may lead to fetal brain cells decrease and affect their mental development, increases the risk of low birth weight and preterm delivery. A zinc deficiency in adult males, may lead to prostatic hyperplasia, reducing the reproductive function of the system and affect fertility.

Vitamin B12: Vitamin B12 has an important role in cellular metabolism, especially in DNA synthesis, methylation and mitochondrial metabolism. The pregnancy and lactation alter maternal B12 status in a manner that facilitates the transfer of B12 to the fetus and infant. B12 deficiency affects the nervous system, resulting in demyelination of peripheral and central neurons. The haematological effect of B12 deficiency is megaloblastic anaemia, which results from disruption of DNA synthesis.

Vitamin B6: Vitamin B6 is required for the synthesis of the neurotransmitters serotonin and norepinephrine and for myelin formation. It helps the body to build protein, make hormones, red blood cells, antibodies and a strong immune system.

Vitamin C: Vitamin C plays an important role in many physiological processes. It enhances iron absorption in the intestine by reducing ferric iron (Fe³⁺) to its more absorbable ferrous form (Fe²⁺). It also helps maintain iron in its usable form within the body and prevents its oxidation. Another important role of vitamin C include the formation of protein used to make skin, tendons, ligaments, and blood vessels for healing wounds and forming scar tissue, for repairing and maintaining cartilage, bones, and teeth and aid in the absorption of iron. It facilitates iron absorption by forming a chelate with ferric iron at acid pH that remains soluble at the alkaline pH of the duodenum.

Dosage and administration

Take one tablet daily, or as recommended by your healthcare professional. For oral use only.

Swallow the tablet whole with a glass of water.

Do not crush, chew, or break it. Do not exceed the recommended dose.

Contraindications

Do not use this product if you are hypersensitive to the active ingredient(s) or any of the excipients of this product.

Side effects

Although not everybody experiences them, the ingredients of this product may cause following side effects; abdominal cramps, gastrointestinal irritation, epigastric pain, constipation, diarrhea, nausea, vomiting, darkened stool, bloating, and dry mouth.

If you experience any serious adverse effects, please consult your healthcare professional.

This includes any possible side effects not listed in this leaflet.

Interactions

Iron, can decrease absorption of bisphosphonates and levothyroxine by forming insoluble complexes in the gastrointestinal tract. Unlike traditional iron salts, ferrous bisglycinate does not require high gastric acidity for absorption, as its chelated structure protects it from degradation in an alkaline environment. As a result, the effect of reduced stomach acidity on its absorption is significantly lower. However, to ensure optimal efficacy, it is still recommended not to take it simultaneously with antacids or proton pump inhibitors.

Ferrous bisglycinate may also form complexes with these antibiotics such as tetracyclines, quinolones or chloramphenicol, and reduce their absorption, although this is less likely compared to ferrous sulfate. It is still recommended to maintain at least a 2-hour interval between their administration.Take care on co-administration of penicillamine, ethambutol, antifolate agents, and anticonvulsant drugs which may get interfere with their effectiveness.

Warning & Precautions

This product is not recommended for children under 12-years old as an acute iron poisoning is a serious risk in the paediatric population. If you have sensitivity to folic acid or iron, an undiagnosed anemia, any existing heart diseases, consult your healthcare professionals before administration of the product and also brief about all the medications you use.

Usage in pregnancy & lactation

This product can be used safely during pregnancy and breastfeeding. For more information, please consult your doctor or pharmacist.

Packaging information

Blister packs of 2x15's tablets.

Condition for preservation and storage

Store below 30 0 C, protect from moisture.
KEEP OUT OF REACH OF CHILDREN.

Producing country name

Iran

Manufacturing company logo

IRC No.

5594478825765147 & 8726170458531110

Testimonials

Dr. Amir Fakhri

Technical Assistant

Since the beginning of the establishment of the pharmacy (2018), due to familiarity with the products, purchases have been made from the basket of Natures Only products. What we can Say to other customers is, Naturesonly products are very high quality, and at the same time, for example, regarding the calcium product, the complication that we see from the Supracal brand is very rare compared to similar products in the market, which is due to the high quality of raw materials.The distinguishing feature of this brand is the packaging and the appropriate number in each package, and the superiority of the Nature Annie brand is the complete basket of products for each group of society, for example, calcium in different amounts of calcium, different amounts of vitamin D and presence of vitamin K. It is usually purchased once a month from the Natures Only  products basket. 90% of those who use the products of the Natures Only  brand do not change the brand for re-use and use the Natures Only brand again. Given that I and my family use your products, I recommend the products to customers and they trust for the same reason and buy the product. Please add a one-dimensional barcode on the product packaging for the convenience of pharmacy staff, And the high price of Natures Only  products compared to similar domestic products make it difficult to purchase for community and thats of course due to specific strategies of Natures Only Company.

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Mr. Mehdi Rahimi

Sound Recordist

Consumer of Cartigen and Supracal D

I first heard the definition of Supracle D from my friends 7 months ago and I am very satisfied and the most important reason for me to use this supplement is that because I have a kidney problem, it does not cause stones and the absorption of vitamin D in it is very high. I also use Cartigen, which was used to repair the problem of leg bone fractures and swollen joints using a 3-month course of Cartigen Forte and Supracal D.

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Alireza Al-Ebrahim

Technical Assistant

The difference between your brand and similar products in the market is the excellent quality of these products, which considering the current economic conditions may be considered a high price for some groups, but it can be justified. Most of our purchases are on Supracal and Cartigen Forte, which I was both satisfied with and received good feedback from the person I offered. If I want to say the reasons why I introduce your brand to patients, the variety of your products in each group of products is different, the quality of your products and that finally the products that we introduce to the customer, give good results and the customer comes back for the next purchase.

All the products that we buy are in the distribution basket that we work with them and we have no problem in supplying Natures Only products.

It often happens that the person consuming the Natures Only brand keeps the brand name for the next purchase, even if he does not have the box with him, and asks us for that product. There are many doctors who prescribe calcium, glucosamine, etc. products as brands such as Supracal, Cartigen.

There is not much prescription for the Double Bull product and it should be done in OTC and the requests are low and it should even be introduced to the patient, but after the introduction, they will definitely welcome and buy it. From your product portfolio, I recommend Supracal and Cartigen Forte to patients. If I have to say my general opinion about your brand, it is a brand that can be trusted in the end.

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Mehrdad Golshani

Sales Representative

Natures Only products have been available in the Day Darou distribution portfolio for about 5 years. Due to the fact that the raw materials for the production of Natures Only products are of higher quality, this feature can be seen in the final product compared to competitors. When we want to introduce products to pharmacies, most offers and payment terms are important to them, and quality is of less importance in pharmacies.  The terms of the offer and refund in Natures Only are acceptable. Pharmacies will definitely follow us for their next purchases, especially for buying Bio-Basics women and Supracal. If I want to say my general opinion about the brand of Natures Only, it is a well-known and reputable brand that has no problem in terms of quality in pharmacies and has been a well-known brand for pharmacies for many years, and this brand is well known by its name.

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Mehdi Habibi

Sales Representative

I've been familiar with Natures Only products for about 4 years and I work with them clearly. The difference I can say about the Natures Only brand is that Supracal is a well-known product and is also branded in the Pharmaceutical basket, so it is easy to trust other products, Of course, I can say that the team of Darogostar Razi made the most effort, because at the time of the product launch, this distribution had worked very well on the products. Since then, the Natures Only brand has been known and needs no definition. If I want to talk about the quality of the products, some of your products are very acceptable to me, such as Supracal, Supracal D and Magtra.

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Dr.Behrooz Yazdani

Rheumatologist

I think I have been prescribing your products to my patients for over 5 years. I would like to say the difference between the products, for example, we use cartigen more in osteoarthritis, and well, because it is a disease that has no cure and patients deal with it daily, we look for a medicine that reduces the patient's pain, and usually the person with this disease is old. And takes medications related to blood pressure, sugar, etc., giving painkillers such as ibuprofen, etc. is not very good, so we are looking for a drug that has analgesic properties without side effects for the patient and our next goal is to be able to wear and destroy reduce cartilage in osteoarthritis and prevent it from progressing.I usually do not prescribe much in the first prescription, but usually patients see the result after taking it and prepare it themselves and use it continuously for 5-6 months.So our original prescription for osteoarthritis is definitely a cartigen. It often happens that patients come to me and say that they also use this medicine for those around them who have osteoarthritis. Because I have been prescribing your products for a long time and patients are satisfied with the result, we are also satisfied. Patients with cartigen use have no side effects, no gastrointestinal side effects, observe the effect of the drug and as a result they do not stop taking the drug. I think Natures Only ingredients are good and I regularly prescribe them to my patients.

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Dr.Behzad Khalilolah

Neurologist

I have been prescribing these products to patients for 2 to 3 years and I have used some of the products myself. The difference between these products and other similar products is that I saw good effectiveness and efficiency of these products and did not see significant side effects of these products and also this brand has a complete basket of all supplements that makes this choice diverse and easy. My dear colleagues, I recommend that if they have indications for their patients to use supplements in all fields, they should use the products of this company, which has been tested and my work experience in the field is without significant side effects.  The company is very reputable with a good and positive history and always tried to be a pioneer in this field by holding congresses and scientific conferences in order to provide scientific information and appreciation of doctors and to be a pioneer among other partner companies. Finally, due to my useful and positive experience of working and using the products of this company, I also recommend to my colleagues to prescribe these drugs for their patients, which will surely see beneficial and positive effects on patients. 

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Dr.Mohammad Hossein Shahbazi

Neurologist

I mostly prescribe Magtra for migraines and muscle spasms, and I prescribe Double Bull for fatigue.The distinguishing feature of your products, for example Magtra, is that it is easily accessible because it does not need to be consumed with water, the patient can carry it in his pocket and consume it at any time, and it has fewer side effects than similar products on the market, and the positive effects I got from this product were more, this does not mean that the products on the market are not responsive, but the positive effect I got from this product was more. Most of our colleagues know your products, but if I want to introduce, I will introduce your products according to the pharmaceutical field of your different products. For example, for migraines, I will definitely introduce Magtra, for MS patients, focus on people and relieve fatigue, I will definitely introduce Double Bull. A product that is good has several features, one of which is that it is easy to access, and the patient can easily buy it from anywhere, and whenever I prescribe it, the patient does not have a problem, does not have a big price increase compared to other products in the market. The packaging is very important, both for the quality of the ingredients over the years and for us and the patient. Natures Only products also have all these features. 

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Majid Sadabadi

writer

Consumer of Supracal product
I have had a problem with scaling of the skin around my nails for a long time and I used calcium products as prescribed by my doctor. I also used Supracle for 6 months and did not see any specific side effects of this product, which according to my doctor, the citrate content of calcium in its components, is the main cause of this case. Also, the effectiveness of this product is not comparable to other calcium products.

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Niloofar Abtahi

Employee

Consumer Sachet Magtra
I have been taking Magtra supplement for more than 2 years after exercise to relieve muscle cramps and spasms. The most important thing for me is enough magnesium and also that I can easily carry it in my exercise bag and consume it without water.

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